Introduction

High-Purity AAS Raw Powder Factory Production And Transportation Process

Strongly Inhibits Estrogen Production

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Multiple Countries Can Issue

Stable Original Factory Direct Supply

Boost Hormone Activity

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Products Description

Precise Physicochemical Fingerprint: High-quality anastrozole possesses a highly clear physicochemical identity. Its internationally recognized CAS number is 120511-73-1, its chemical name is α,α,α',α'-tetramethyl-5-(1H-1,2,4-triazol-1-methyl)-1,3-phenyleneacetonitrile, its molecular formula is C₁₇H₁₉N₅, and its molecular weight is precisely 293.37. In appearance, top-grade pharmaceutical or research-grade raw materials are white to off-white crystalline powders with a stable melting point between 81℃ and 86℃. Its density is approximately 1.1 g/cm³, exhibiting extremely high chemical stability at room temperature. Regarding solubility, anastrozole is highly soluble in dimethyl sulfoxide (DMSO, with a solubility of 34-40 mg/mL), slightly soluble in ethanol, and almost insoluble in water. The highly pure crystal structure and specific solubility properties of this product provide a reliable physical basis for its precise formulation in subsequent cell and animal experiments.

Highly Selective Pharmacological Mechanism and Core Advantages As a potent and highly selective aromatase (CYP19A1) inhibitor, the core advantage of high-quality anastrozole lies in its "precision targeting" capability. The triazole group in its molecular structure can reversibly bind to the heme group in the cytochrome P-450 unit of aromatase, thereby competitively inhibiting the enzyme's activity. Its inhibitory efficacy against aromatase is extremely strong (IC50 = 15 nM), hundreds of times more potent than earlier inhibitors, and it has almost no effect on the synthesis of other steroid hormones (such as adrenocortical hormones). This high selectivity allows it to efficiently block the conversion of androstenedione to estrone in peripheral tissues (such as fat and muscle) of postmenopausal women, reducing plasma estradiol levels below the detection limit, thereby cutting off the nutrient supply to estrogen-dependent tumor cells.

Multidimensional Scientific and Application Value: The high purity (typically ≥98% or 99%) of top-grade raw materials ensures accuracy and reproducibility in experimental studies. Besides being a classic endocrine therapy drug for breast cancer, it has also demonstrated unique application potential in research models involving estrogen regulation, such as adolescent dwarfism and polycystic ovary syndrome. Its long half-life of approximately 40 to 50 hours supports once-daily dosing, providing an extremely stable time window for long-acting hormone regulation models.

In summary, high-quality anastrozole raw material, with its well-defined physicochemical parameters, excellent enzyme inhibitory selectivity, and stable pharmacokinetic characteristics, consistently occupies an irreplaceable and unique niche in anti-tumor drug development and endocrine biochemical research.