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Product Introduction
Name:Aicar
Product Benefits:Improve athletic performance and endurance
CAS:681006-28-0
Capacity:10mg*100/bottle
Product Form:Sarms Finished Tablets(Hepius)
Shelf Life:2-3Years(The product packaging date shall prevail)
What is HEPIUS Aicar?
HEPIUS brand AICAR (full name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a chemical substance that is often used in research, especially in research related to metabolism, exercise, and cell biology. AICAR is an adenylate analog that affects cellular energy metabolism by activating the AMP kinase (AMPK) pathway, and is therefore sometimes used as a tool to study energy metabolism.
Physical and chemical properties
- **Chemical formula**: C9H13N7O5
- **Molecular weight**: 299.25 g/mol
- **Appearance**: White or off-white crystalline powder
- **Solubility**: AICAR is easily soluble in water and buffer, but has low solubility in organic solvents. Its solubility and stability may vary in different solvents and pH values.
- **Stability**: AICAR has good stability in aqueous solutions, but may decompose at high temperatures or in strong acid or alkaline environments.
Mechanism of action
AICAR regulates cellular energy metabolism by activating AMPK (AMP-activated protein kinase). AMPK is a key enzyme that senses energy status in cells. When the intracellular ATP level decreases, AMPK is activated, thereby promoting energy generation processes (such as fatty acid oxidation and glycogenolysis) and inhibiting energy consumption processes (such as synthesis reactions) in cells.
In exercise and metabolic research, AICAR is often used to simulate the AMPK activation effect similar to that brought about by exercise, because it can activate the AMPK pathway, thereby improving muscle endurance and increasing fat oxidation. AICAR is used by some athletes and fitness enthusiasts as a supplement to enhance physical fitness, but this practice is considered a banned drug in many sports organizations.
Dosage
The specific dose of AICAR depends on the purpose of application. Usually a lower dose is used in animal experiments, while in clinical experiments, the dose needs to be determined according to the design and objectives of the specific study. In general, the dose of AICAR can be divided into the following categories:
- **Animal studies**: Typical doses range from 1 to 10 mg/kg body weight, usually administered by injection.
- **Clinical studies**: The dose is usually lower, generally in the range of 2 to 5 mg/kg body weight, but this needs to be adjusted according to the specific purpose of the study.
Half-life
The half-life of AICAR varies depending on the method of administration, dosage, and individual differences. Generally speaking, the half-life after administration by injection is between a few hours and more than ten hours. The clearance of AICAR in the body is mainly through renal and liver metabolism and excretion.
Cycle and use
In animal experiments, the use cycle of AICAR is usually a few days to a few weeks to observe the effects of long-term use on metabolism and exercise endurance. In clinical studies, the use cycle depends on the specific study design and can be short-term (a few days to a few weeks) or long-term intervention.
Precautions and side effects
AICAR has fewer side effects, but its use still needs to be cautious, especially in high doses or long-term use. Common side effects may include:
- **Metabolic disorders**: Since the mechanism of action of AICAR is to regulate metabolism by activating AMPK, it may cause disorders in energy metabolism in the body, affecting sugar metabolism, fat metabolism, etc.
- **Excessive improvement of sports performance**: Some athletes may overuse AICAR to improve their performance, but this method of use may bring side effects or dependence.
In some cases, the use of AICAR may be considered prohibited, especially in competitive sports, because it can improve athletic performance in a non-physiological way, similar to the effect of hormone-like drugs.
Clinical application
Currently, AICAR is mainly in the experimental stage and has not been widely used in clinical treatment. However, in some studies, AICAR is considered as a potential drug for the treatment of metabolic diseases (such as diabetes, obesity) and muscle diseases. It mainly improves insulin sensitivity and promotes fat metabolism, which may help regulate body weight and improve muscle function.
Working principle of HEPIUS Aicar
HEPIUS brand AICAR (also called Aicar, chemical name 5-Aminoimidazole-4-carboxamide ribonucleotide) is a compound commonly used in molecular biology research and is also used by some people to improve athletic performance. The main function of AICAR is to regulate metabolism by activating AMP-activated protein kinase (AMPK). The following is a detailed introduction to its applicable population, working principle, usage and dosage:
1. Applicable population
AICAR is usually used in the following populations:
- **Athletes and fitness enthusiasts**: AICAR can help improve fat oxidation, endurance and athletic performance by activating AMPK, and is often used by some athletes as an auxiliary agent to improve athletic performance.
- **Patients with metabolic-related diseases**: AICAR is also used in some studies to treat metabolic-related diseases such as diabetes and obesity. It helps improve metabolic status by regulating energy balance in cells.
- **Scientists and laboratory studies**: AICAR is widely used in biomedical research as an experimental drug, especially in the study of metabolism, fatty acid oxidation and AMPK-related signaling pathways.
2. How it works
AICAR works by activating **AMPK** (AMP-activated protein kinase), a key cellular energy-regulating enzyme. Specifically:
- When energy levels in cells are low (e.g., ATP decreases, AMP increases), AMPK is activated, which promotes energy production and inhibits energy consumption.
- As an AMP-like molecule, AICAR can activate AMPK, which in turn promotes fatty acid oxidation, changes in glucose metabolism, and enhances the cell's ability to respond to metabolic stress.
- Through this mechanism, AICAR can improve endurance, accelerate fat burning, and in some cases may even promote muscle fat oxidation efficiency and healthy metabolic function.
3. Dosage and Administration
The amount and method of using AICAR generally depends on the individual's health status, goals, and whether it is used for research purposes. The following are common ways of use:
- **Athletes and fitness people**: AICAR is not a common supplement, so there is no strict recommended dosage. In clinical studies, AICAR doses are usually in the **250–1000 micrograms** range, and are mostly administered in the form of injections. It is usually injected before exercise to improve endurance and fat oxidation.
- **Research use**: In animal experiments, the dose of AICAR will be determined according to the needs of the research. The common animal experimental dose is **0.5–1 mg/kg** of body weight.
> Note: AICAR, as a drug, usually requires the guidance of a doctor in clinical application, and due to possible side effects, especially the effects of long-term use on metabolism, professional medical personnel must be consulted before use. Especially in the absence of clear medical instructions, personal use is not recommended.
Summary
AICAR promotes fat oxidation and energy metabolism by activating AMPK, which has a certain effect on improving athletic performance, but due to its potential side effects and uncertainty in use, it is recommended to use it under professional guidance and avoid self-abuse.
Advantages of HEPIUS Aicar
HEPIUS brand Aicar (5-Aminoimidazole-4-carboxamide ribonucleotide) is a compound that has been widely studied and used to improve athletic performance and health. It is an AMP-activated protein kinase (AMPK) activator. AMK activators are widely used to regulate cellular energy metabolism, helping to improve athletic ability, promote fat burning, enhance metabolic function, etc. Aicar can promote the metabolism of glycogen, fat and protein and improve health by acting on AMPK.
1. Improve athletic performance and endurance
Aicar promotes energy metabolism in cells by activating AMPK. AMPK is an "energy sensor" in the body. When energy supply is insufficient, it will initiate a series of reactions to improve energy production and use efficiency. Aicar can increase the level of ATP (the energy currency of the cell) in the body, enhance muscle endurance and athletic performance, especially in long-term endurance training.
#### Specific manifestations are:
- Enhance oxygen utilization efficiency in endurance training.
- Increase energy supply during exercise and reduce fatigue.
- Improve muscle glucose metabolism, reduce lactic acid accumulation, and prolong exercise time.
2. Promote fat oxidation and fat burning
Aicar has a significant effect on fat burning. By activating AMPK, Aicar stimulates fatty acid oxidation and inhibits fat synthesis. This effect can effectively improve body fat ratio and reduce abdominal fat.
#### Specific manifestations:
- Increase fatty acid oxidation in fat cells and promote fat burning.
- Help reduce body fat, especially abdominal fat.
- Regulate body fat metabolism and improve fatty acid utilization efficiency.
3. Improve insulin sensitivity and regulate blood sugar levels
Aicar can also improve insulin sensitivity by promoting AMPK activity and has a positive effect on blood sugar regulation. It can increase muscle tissue's uptake and utilization of glucose and improve glucose metabolism, which has potential benefits for diabetic patients or people with poor blood sugar control.
#### Specific manifestations:
- Improve muscle's ability to absorb glucose and reduce blood sugar fluctuations.
- Improve insulin sensitivity and help prevent and relieve type 2 diabetes.
- Regulates fat metabolism, helping to reduce metabolic problems associated with diabetes.
4. Increases muscle mass and improves muscle function
Aicar indirectly promotes muscle protein synthesis through the AMPK pathway. Studies have shown that Aicar can enhance muscle mitochondrial production and improve the energy utilization efficiency of muscle cells, thereby helping to improve strength and muscle mass.
#### Specifically manifested as:
- Stimulates mitochondrial production and improves energy supply to muscle cells.
- Improves recovery after exercise and reduces muscle soreness and fatigue.
- Enhances muscle adaptability to training and improves muscle strength.
5. Improves cardiovascular health
Aicar can not only promote fat burning but also improve vascular function by activating AMPK. It improves the health of the cardiovascular system by improving mitochondrial function.
#### Specifically manifested as:
- Improves the health of the heart and blood vessels and reduces the risk of cardiovascular disease.
- Reduces cardiovascular burden by regulating fatty acid metabolism.
- Improves vascular elasticity and blood circulation.
6. Improve overall metabolic health
Aicar, as an AMPK activator, has a significant impact on overall metabolic health. It promotes overall metabolic balance by affecting fat metabolism, sugar metabolism, and protein metabolism.
#### Specific manifestations:
- Enhance energy metabolism and increase basal metabolic rate (BMR).
- Improve overall metabolic levels and prevent the occurrence of metabolic diseases such as obesity.
- Help reduce chronic inflammatory responses and help improve health.
7. Potential anti-aging effects
Aicar is also considered to have potential in the field of anti-aging due to its AMPK activation effect. Increased AMPK activity may be associated with enhanced cellular autophagy and antioxidant mechanisms, which are important for delaying aging, improving lifespan, and fighting aging diseases.
#### Specific manifestations:
- Delay the aging process by increasing cellular autophagy and removing senescent cells.
- Promote mitochondrial function and delay the decline in cellular energy associated with aging.
- Improve the body's antioxidant capacity and reduce oxidative stress.
8. Possible anti-cancer effects
Studies have shown that Aicar may inhibit the proliferation of cancer cells through the AMPK pathway. AMPK plays an important role in the anti-cancer mechanism, inhibiting the growth and expansion of cancer cells.
#### Specific manifestations are:
- Slowing down the growth rate of tumors by inhibiting the proliferation of cancer cells.
- Regulating energy metabolism, which helps reduce the occurrence of cancer.
- Enhancing the resistance of cells to malignant transformation.
Summary
As an AMPK activator, HEPIUS brand Aicar has a variety of potential benefits, especially in terms of athletic performance, fat metabolism, insulin sensitivity and overall metabolic health. It not only helps to improve endurance, promote fat burning, and improve blood sugar control, but may also have a certain preventive effect on aging and cancer. Of course, since the effects of Aicar may vary in different individuals, it is best to use it under the advice of professionals before use, especially for patients with certain specific diseases.
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FAQ
Q: How does AICAR work on cells?
A: As an AMPK agonist, AICAR can promote the activation of AMPK in cells by simulating energy stress (such as exercise or hypoxia). After AMPK is activated, it can inhibit energy-consuming biosynthetic processes (such as the synthesis of fats and sugars) and stimulate energy-generating processes (such as the oxidation of fatty acids and the uptake of glucose). This series of reactions helps cells maintain normal function when energy supply is short.
Q: What is the relationship between AICAR and exercise?
A: AICAR is often used to simulate the effects of exercise on the body. During exercise, energy consumption in muscle cells increases, which activates AMPK. By using AICAR, researchers can simulate this metabolic change without actual exercise. Studies have found that AICAR can improve exercise endurance, promote fat oxidation, improve insulin sensitivity, and may even promote muscle growth. Therefore, it is considered to have potential performance-enhancing effects.
Q: What are the applications of AICAR in medical research?
A: AICAR is widely used in basic medical research, especially in the study of metabolic diseases, diabetes, cardiovascular diseases, and obesity. Because of its ability to improve cellular energy metabolism, AICAR is studied as a potential therapeutic tool for treating metabolic disorders, improving exercise capacity, and reducing obesity. In animal models, AICAR has been found to improve insulin sensitivity, reduce body weight, and improve heart function.
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