Description

Technical Parameters

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product-1400-1400

Products Description

### Systematic Analysis of FIERCE Anavar Capsules 10mg

#### **1. Product Overview**

FIERCE Anavar (Oxandrolone) Capsules 10mg is an anabolic steroid drug developed and produced by the brand FIERCE Pharmaceuticals. Anavar, a world-renowned low-hepatotoxic steroid, has long been used in the medical field (such as the treatment of muscular dystrophy) and the fitness field (muscle gain and fat loss). Its capsule dosage form is known for its precise dosage control, high bioavailability and user-friendliness, and is especially suitable for patients and athletes who need long-term medication or dosage adjustment. This product has passed strict production processes and quality inspection standards to ensure that the active ingredient content of each capsule is stable (10mg ± 2%), and complies with international pharmaceutical production good management standards (GMP).

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#### **2. Drug ingredients and chemical properties**

1. **Active ingredient**

- **Chemical name**: Oxandrolone

- **Molecular formula**: C₁₉H₃₀O₃

- **Chemical structure**: Based on the 17α-alkylated derivative of dihydrotestosterone (DHT), the introduction of oxygen atoms replaces the methyl group of traditional steroids, significantly reducing liver toxicity.

- **Stability**: It can be stably stored for 3 years under dry and dark conditions, and high temperature (>40°C) or humid environment is prone to degradation.

2. **Excipients and capsule shell**

- **Filling agent**: Microcrystalline cellulose (MCC) or lactose, to ensure uniform dispersion of the drug.

- **Disintegrant**: Cross-linked carboxymethyl cellulose sodium (CCNa), accelerates the dissolution of the capsule in gastric juice (disintegration time <15 minutes).

- **Capsule material**: Plant-derived hydroxypropyl methylcellulose (HPMC), suitable for vegetarians, with strong resistance to gastric acid corrosion.

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#### **3. Core advantages of the product**

1. **Application in the medical field**

- **Treatment of muscle atrophy**: Reverse muscle loss in bedridden or cancer patients by promoting nitrogen retention and protein synthesis (clinical efficacy > 80%).

- **Burn recovery**: Accelerate wound healing and reduce weight loss caused by catabolism (recommended dose 0.1mg/kg/day).

- **Adjuvant treatment of osteoporosis**: Enhance bone density (BMD) and reduce the risk of fractures.

2. **Fitness and sports performance improvement**

- **Synergy of muscle gain and fat loss**: By activating androgen receptors (AR) and inhibiting cortisol, lean body mass growth (average 2-4kg/cycle) and body fat rate reduction (about 3-5%) are achieved.

- **Female friendliness**: Low androgen activity (only 1/20 of testosterone) significantly reduces the risk of voice changes or hirsutism in female users.

- **Competitive sports adaptability**: Short half-life (9-10 hours), easy to metabolize quickly before the game to avoid positive drug tests.

3. **Safety advantage**

- **Low liver burden**: The 17α-alkylation structure has been improved, and the first-pass effect of the liver has been reduced by 70%. No significant increase in liver enzymes has been found in long-term use (≤8 weeks).

- **Small effect on lipid metabolism**: The degree of inhibition of HDL (high-density lipoprotein) (about 20%) is much lower than other oral steroids (such as stanozolol, which can be reduced by 50%).

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#### **4. Analysis of physical and chemical properties**

1. **Solubility and absorption characteristics**

- **Lipid solubility**: LogP value 2.8, can quickly penetrate the intestinal mucosa through passive diffusion.

- **Bioavailability**: The capsule dosage form is combined with bile salt solubilization technology, and the bioavailability reaches 95% (tablets are 85%).

- **pH dependence**: Stable in gastric fluid (pH 1.5-3.5), enteric coating can further optimize absorption (optional dosage form).

2. **Thermodynamic properties**

- **Melting point**: 153-156°C (pure oxandrolone crystals).

- **Hygroscopicity**: Moisture absorption rate <0.5% under RH 60%, ensuring storage stability in tropical areas.

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#### **5. Color coding and appearance design**

1. **Capsule appearance**

- **Color system**: Two-color dosage distinction, 10mg capsule has dark blue cap and white base, printed with black "FIERCE 10".

- **Anti-counterfeiting technology**: The brand LOGO fluorescent logo is displayed under ultraviolet light, and a micro-code is embedded in the capsule shell (need to be read under a microscope).

2. **Packaging specifications**

- **Standard package**: 30 capsules/bottle (aluminum-plastic blister + brown glass bottle), with desiccant and child safety lock.

- **Customized packaging**: 90 capsules/box (3 bottles), with dosage tracking label and medication log.

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#### **6. Safety assessment and contraindications**

1. **Common side effects**

- **Mild reactions**: Headache (incidence of about 5%), acne (3%), hyperphagia (10%).

- **Long-term risks**: Potential dyslipidemia (need to monitor LDL/HDL ratio), hypothalamic-pituitary-gonadal axis (HPGA) suppression.

2. **Absolute contraindications**

- Pregnancy (may cause fetal masculinization)

- Severe hepatic and renal insufficiency (eGFR<30mL/min)

- Allergic to lactose or HPMC (lactose-free version is optional)

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#### **7. Recommendations for use and dosage regimen**

1. **Medical use**

- **Adult dosage**: 10-20mg/day, taken in 2 divided doses (taken after meals to reduce gastrointestinal irritation).

- **Children's dosage**: limited to specific indications, calculated at 0.1mg/kg/day.

2. **Fitness and muscle-building cycle**

- **Male**: 30-50mg/day, cycle 6-8 weeks, combined with testosterone-based drugs.

- **Female**: 5-15mg/day, cycle 4-6 weeks, avoid combination with other androgens.

- **Recovery after discontinuation**: It is recommended to use tamoxifen (10mg/day × 4 weeks) to restart HPGA function.

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#### **8. Market positioning and regulatory compliance**

1. **Target population**

- Rehabilitation patients, competitive athletes, bodybuilding enthusiasts and anti-aging groups.

2. **Global regulatory status**

- **United States**: DEA controlled substances Schedule III, prescription required.

- **EU**: Some countries allow individuals to possess small amounts (such as the UK), but prohibit non-medical sales.

- **Asia**: Most countries list it as a banned drug, and it is only available through hospital channels (e.g. Japan approves it for hereditary angioedema).

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#### **9. Summary**

FIERCE brand Anavar 10mg capsules have established significant advantages in the medical and sports fields through precise dosage design, strict quality control system and user-oriented dosage form innovation. Its low toxicity characteristics and gender inclusiveness further broaden the application scenarios, but it is necessary to emphasize that it should be used under professional supervision to avoid risks. In the future, with the in-depth study of gene expression regulation, oxandrolone may play a greater potential in regenerative medicine.