Product Introduction
Name:Flibanserin
Product Benefits:Deep muscle training, posture correction and body shaping
CAS:167933-07-5
Capacity:100mg*30/bottle
Product Form:Tablets
Shelf Life:24 Months(The product packaging date shall prevail)
What is Flibanserin
1. Basic information
Generic name: Flibanserin
Chemical name: 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-
CAS registration number: 167933-07-5
Molecular formula: CHNOPS (the specific molecular formula structure is relatively complex and requires reference to professional chemical information)
2. Pharmacological action
Flibanserin is an orally active drug with the following main mechanisms of action:
5-HT receptor regulation: Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist of 5-HT. This dual action can regulate the level of neurotransmitters related to sexual desire.
Dopamine receptor binding: Flibanserin can also bind to dopamine D4 receptors, further affecting the neurotransmission process, which may have a positive effect on sexual desire.
3. Indications and Uses
Flibanserin is mainly used to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This disorder is characterized by low sexual desire leading to significant distress or difficulty in interpersonal communication, and is not caused by the influence of drugs or other substances.
4. Medication Instructions
Recommended dose: usually 100 mg per day, taken before bedtime. This is because taking it while awake may increase the risk of hypotension, syncope, accidental injury and central nervous system depression.
Treatment cycle: If there is no improvement after 8 weeks of treatment, treatment should be considered for termination.
Contraindications: including simultaneous use with alcohol, simultaneous use of moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors, and patients with liver damage.
5. Precautions and side effects
Precautions:
Alcohol should be prohibited during the use of Flibanserin, as the combined use of the two increases the risk of severe hypotension and syncope.
Before prescribing, health care providers should assess the patient's possibility of giving up alcohol use and discuss the importance of giving up alcohol use.
Flibanserin is only available through a specific restricted procedure to ensure safe use.
Side effects:
Long-term use of Flibanserin may cause side effects such as nausea, drowsiness, dizziness, hypotension and syncope.
Especially when used with alcohol, it increases the risk of fainting and accidental injury.
6. Market situation
Flibanserin (marketed under the trade name Addyi) was approved by the U.S. Food and Drug Administration (FDA) in 2015, becoming the first drug in history to be used for female sexual desire disorder.
Despite market demand, the launch and popularization of Flibanserin also faces some challenges, including side effects, restrictions on use, and public awareness and acceptance of sexual desire disorder.
How Flibanserin Works
Flibanserin is an orally active drug that works primarily by interacting with specific neurotransmitter receptors.
1. Drug Mechanism
5-HT Receptor Action
Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist for 5-HT.
As a 5-HT1A receptor agonist, Flibanserin increases the activity of this receptor, which is often associated with antidepressant and antianxiety effects.
As a 5-HT2A receptor antagonist, Flibanserin inhibits the activity of this receptor, which helps regulate neurotransmitter balance in the brain.
Dopamine Receptor Action
Flibanserin can also bind to dopamine D4 receptors, which further enhances its role in regulating neurotransmitter balance.
2. Clinical Application
Treatment of Hyposexuality
Flibanserin is mainly used to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.
By regulating the balance of neurotransmitters in the brain, Flibanserin can improve the symptoms of low sexual desire in women.
Non-hormonal properties
Compared with traditional hormone therapy, Flibanserin, as a non-hormonal drug, has fewer adverse reactions and drug dependence.
3. Drug metabolism and safety
Metabolic pathway
Flibanserin can be converted into two non-toxic degradation products DP1 and DP2 after oxidative degradation in the body.
Safety and precautions
Although Flibanserin has a certain efficacy in the treatment of HSDD, it is still necessary to pay attention to its possible adverse reactions and drug interactions when using it.
Patients should consult a doctor before use to understand the use and precautions of the drug.
What is the recommended dosage and use of Flibanserin?
Flibanserin is a new non-hormonal drug mainly used to treat low sexual desire disorder (HSDD) in women. The specific information about its recommended dose and usage is as follows:
Recommended dose
The recommended dose of Flibanserin is 100 milligrams (mg) per day, that is, take 1 100 mg tablet each time.
How to use
Flibanserin should be taken at bedtime. This is because taking it during wakefulness may increase the risk of hypotension, fainting, accidental injury, and central nervous system (CNS) depression (such as sleepiness and sedation).
If a dose of Flibanserin is missed before bedtime, it should be continued at the regular dose before bedtime the next day, and do not double the dose to make up for the missed dose.
In terms of treatment cycle, if the patient does not observe symptom improvement after 8 weeks of continuous treatment, the treatment should be considered to be terminated.
Precautions
The simultaneous use of Flibanserin and alcohol will significantly increase the risk of hypotension and fainting, so drinking is prohibited during use.
Concomitant use of flibanserin with moderate or potent cytochrome P450 3A4 (CYP3A4) inhibitors may increase drug concentrations, leading to hypotension and syncope, so concomitant use with such drugs is contraindicated. If such drugs are needed, they should be started at least 2 days after stopping flibanserin, or flibanserin should be stopped at least 2 days before starting such drugs.
Flibanserin is not suitable for postmenopausal women, men, children, patients with liver dysfunction, and pregnant and lactating women (animal experiments have shown that this product can be excreted through breast milk, but it has not yet been determined whether this product can be excreted through human milk. Lactating women should stop breastfeeding when using it).
During the use of flibanserin, patients should avoid activities that require high concentration, such as operating machinery or driving, to prevent danger.
Benefits of Flibanserin in Fitness
The benefits of Flibanserin in fitness are mainly reflected in the following aspects:
1. Deep muscle training
Efficient effect: Based on the principle of resonance, Flibanserin can effectively act on the deep muscles of the body. These deep muscles are often difficult to fully exercise in traditional sports.
Comprehensive exercise: When using Flibanserin for exercise, not only the deep muscles of the abdomen will be strengthened, but also the deep muscles of the buttocks, chest and arms will be exercised at the same time.
2. Posture correction and shaping
Beautify the body: The exercise method of Flibanserin can beautify the body posture very effectively and correct bad postures such as hunchback.
Shaping lines: Continuous Flibanserin training can shape the perfect body lines, making the body more compact and stylish.
3. Treatment and prevention of diseases
Relieve pain: Flibanserin has a significant effect on the treatment or prevention of low back and shoulder diseases. It can strengthen the deep trunk muscles, stabilize the spine in a short time, improve body shape, and prevent back pain and intervertebral disc problems.
Enhanced function: For the elderly, the Flyx stick can enhance joint function, reduce pain, and prevent osteoporosis and falls by exercising deep muscles.
4. Wide range of applicable people
Different needs: The Flyx stick is suitable for fitness enthusiasts of all levels, whether athletes, office workers, sub-healthy people, or the elderly and children, all can benefit from it.
Easy to carry: The Flyx stick is lightweight and portable, and can be used anytime and anywhere, whether at home, in the office or outdoors, you can exercise.
5. Other benefits
Improve concentration: Teenagers can improve their concentration by using the Flyx stick for training.
Increase metabolism: Exercise with the Flyx stick can promote metabolism, which helps physical health and weight management.
Contact Details(WhatsApp Telegram ) And Payment Methods
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FAQ
Q: How does Flibanserin treat HSDD?
A: Flibanserin competes with 5-hydroxytryptamine (5-HT) to bind to receptors on the postsynaptic membrane, preventing 5-HT from exerting its inhibitory effect on sexual desire, thus weakening the central nervous system's inhibitory response to sexual desire, increasing the level of dopamine that stimulates sexual desire, and increasing excitability, thereby achieving the purpose of treating HSDD.
Q: What are the main clinical research results of Flibanserin?
A: A study funded by the German pharmaceutical company Boehringer Ingelheim and jointly participated by the University of North Carolina, the University of Virginia, the Women's Health Center of the Ottawa Hospital in Canada, and the University of Pavia in Italy showed that Flibanserin showed good efficacy and tolerability for hyposexuality (HSDD) in premenopausal women.
Q: Question 5: What are the main contraindications and precautions of Flibanserin?
A: Answer 5: The main contraindications of Flibanserin include: patients with severe liver damage, hypotension, and a history of alcohol or drug abuse are prohibited from using it; pregnant women, breastfeeding women, and children are also not suitable for use. The main precautions include: avoid drinking or limit alcohol intake during use to avoid affecting the metabolism and absorption of the drug; patients with cardiovascular disease should consult a doctor before use; it may cause adverse reactions such as drowsiness or inattention, and should avoid driving a motor vehicle or operating mechanical equipment that requires high concentration during use.
Q: Question 6: What are the possible side effects of Flibanserin?
A: Answer 6: The side effects of Flibanserin may include nausea, drowsiness, dizziness, hypotension, and syncope. Especially when used with alcohol, it may increase the risk of syncope and accidental injury.
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