HEPIUS T4（Levothyroxine）40mcg CAS:51-48-9

Your body produces two main hormones, thyroxine (T4) and triiodothyronine (T3). Levothyroxine is a man-made thyroxine that is used in patients to replace the thyroxine that their bodies cannot produce.

While it starts working immediately, it takes about 8-10 days to fully enter your system and for you to start feeling better. However, some people report a reduction in symptoms before then.

Treatment usually starts with 25 micrograms or 50 micrograms per day, depending on the severity of the condition. Tests are done at varying intervals, and the dose is increased over the next few weeks and months until the test results show that they are within the normal range and your symptoms are relieved.

The tests commonly used to check your levels are the thyroid stimulating hormone (TSH) test and the free thyroxine (FT4) test.

Generally speaking, people feel good when levels are within range, but everyone is different and you may feel best at a specific level within that range.

According to the British Medical Association's booklet Understanding Thyroid Disease (written by Dr Anthony Toft), many people do not feel unwell unless their TSH levels are at or below the bottom of the TSH range and at or just above the top of the FT4 range. Dr. Toft also stated in Pulse Magazine in 2010:

"The appropriate dose of levothyroxine is to restore euthyroidism and restore serum TSH to the lower part of the reference range - 0.2-0.5mU/l.

In this case, free thyroxine may be at the upper end of the reference range or slightly elevated - 18-22pmol/l. Most patients will feel fine in this situation.

But some people need higher doses of levothyroxine to suppress serum TSH, and then the serum free T4 concentration will rise to around 24-28pmol/l.

As long as serum T3 is absolutely normal, that is, total serum T3 is about 1.7nmol/l (reference range 1.0-2.2nmol/l), this 'exogenous subclinical hyperthyroidism' is not dangerous."

Levothyroxine is produced by different pharmaceutical companies in various brand names and generics (copycats of brand names). The ingredients of these drugs vary. Some medicines contain lactose, so for people with lactose intolerance, it may be best to look for lactose-free versions of levothyroxine.

We are finding that more and more people are intolerant to another ingredient, mannitol, which has been used to replace lactose in some tablets.

Some people are intolerant to certain fillers and binders in levothyroxine tablets, and we know that some people are intolerant to one specific type of levothyroxine, anhydrous levothyroxine.

Most people will have no problems taking levothyroxine. For those who have questions about certain ingredients, try to find the ingredient or generic version of the medicine you are questioning.

Some brands of tablets are lactose- and mannitol-free, and some compounding pharmacies (pharmacy that makes tablets to order) can make levothyroxine tablets with little or no fillers and binders, or with fillers and binders that are less likely to cause problems.

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1. How long does it take to see the effect after taking T4?

After taking T4, the time it takes for its effects to appear varies from person to person, but some changes can usually be observed within a few weeks. Specifically:

Initial effect: Within the first few weeks after taking T4, patients may begin to feel some initial effects, such as improved mental state and reduced fatigue. These changes are usually caused by increased thyroid hormone levels.

Obvious effect: Generally speaking, thyroid hormone levels can basically return to normal levels after taking T4 for about 4 to 6 weeks. At this time, patients may feel more obvious symptom improvement, such as weight loss (if weight gain was previously caused by hypothyroidism), normal heart rate, and improved dry and rough skin.

Stable period: After reaching the stable period, patients need to continue taking T4 to maintain normal thyroid function. At this time, the doctor will perform regular thyroid function tests to ensure that the drug dosage is appropriate and make necessary adjustments based on the test results.

2. Is it necessary to take T4 for a long time?

For most patients with hypothyroidism, long-term use of T4 is necessary. Here are the reasons:

The nature of hypothyroidism: Hypothyroidism is usually caused by insufficient secretion of thyroid hormones due to damage or hypofunction of the thyroid gland. T4, as a synthetic thyroid hormone, can supplement the thyroid hormones that are lacking in the patient's body, thereby relieving symptoms and maintaining normal thyroid function.

Preventing symptom recurrence: If you stop taking T4, the symptoms of hypothyroidism are likely to reappear. This is because the patient's thyroid gland still cannot produce enough thyroid hormone to meet the needs of the body.

Maintaining quality of life: By taking T4 for a long time, patients can maintain normal thyroid function, thereby maintaining a good physical and mental state. This is beneficial for improving quality of life, preventing complications and prolonging life.

Precautions

Follow the doctor's advice: During the period of taking T4, patients should strictly follow the doctor's advice for medication and monitor thyroid function regularly.

Drug interactions: Be careful to avoid taking it at the same time with other drugs that may affect the absorption of T4. If you need to take other drugs at the same time, please consult a doctor or pharmacist.

Dietary adjustments: Certain foods may also affect the absorption of T4, such as high-fiber foods, soy products, etc. During the period of taking T4, patients should consult a doctor for dietary advice.

The benefits of using T4 (Levothyroxine) are mainly reflected in the following aspects:

1. Treatment of hypothyroidism

T4 is the main treatment for hypothyroidism (hypothyroidism). Hypothyroidism is caused by the thyroid gland's inability to produce enough thyroid hormone to meet the body's needs, resulting in symptoms such as slowed metabolism, weight gain, fatigue, dry and rough skin. T4 can replenish the lack of thyroid hormone in the body, thereby:

Relieve symptoms: such as fatigue, weight gain, dry skin, etc.

Increase metabolic rate: Enable the body to use energy more efficiently.

Improve cardiovascular health: Reduce the risk of heart disease, because thyroid hormone is essential for heart function.

2. Prevent goiter recurrence

For patients who have undergone thyroidectomy, T4 can prevent the recurrence of goiter. By supplementing thyroid hormone, the pituitary gland can be inhibited from secreting thyroid-stimulating hormone (TSH), thereby reducing the proliferation and enlargement of thyroid tissue.

3. Auxiliary treatment of other thyroid diseases

T4 can also be used as an adjuvant treatment for other thyroid diseases, such as adjuvant treatment of hyperthyroidism with antithyroid drugs, and suppressive treatment after thyroid cancer surgery. In these cases, T4 can help regulate thyroid function and keep it within the normal range, thereby alleviating symptoms and reducing the risk of complications.

4. Improve quality of life

By maintaining normal thyroid function, T4 can significantly improve the patient's quality of life. This includes improving mental state, enhancing immunity, improving sleep, and reducing anxiety. In addition, T4 can also help patients better cope with the stress and challenges of daily life.

5. Promote growth and development

Thyroid hormones are essential for children's growth and development. In children and adolescents, appropriate T4 intake can promote bone and muscle growth, as well as intellectual development. Therefore, T4 treatment is particularly important for children and adolescents with hypothyroidism.

Precautions

Although T4 has many benefits, the following points should also be noted when using it:

Use medication as prescribed by a doctor: Patients should take T4 strictly according to the doctor's instructions and monitor thyroid function regularly.

Pay attention to drug interactions: Avoid taking it at the same time with other drugs that may affect T4 absorption or metabolism.

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