Knowledge Content
#### 1. Central Nervous System: Rebalances Neurotransmitters Related to Sexual Desire
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It primarily acts on the limbic system (the core area responsible for emotion and reward) by bidirectionally regulating three key neurotransmitters:
- **Inhibition of 5-hydroxytryptamine (5-HT) Receptors**: Blocks the inhibitory signals of 5-HT2A/2C receptors on sexual desire, reducing neural impulses related to "sexual aversion." Clinical data show that after four weeks of treatment, women's psychological aversion to sexual stimulation decreased by 38%;
- **Activation of Dopamine (DA) and Norepinephrine (NE) Pathways**: Promotes dopamine release (enhancing sexual reward) while simultaneously increasing norepinephrine levels (improving the neural transmission of sexual arousal), increasing the brain's sensitivity to sexual signals by 2-3 times without the side effects of increased heart rate similar to stimulants.
#### 2. Endocrine Level: Indirect Regulation of Hormone Metabolism
Although it does not directly supplement sex hormones, long-term use can slightly improve the endocrine environment:
- It reduces adrenocorticotropic hormone (ACTH) levels, alleviates stress-related elevated cortisol levels (high cortisol can suppress libido), and restores the circadian rhythm of cortisol to normal in 62% of women.
- It has no significant effect on the concentrations of sex hormones such as estrogen and testosterone, thus avoiding the risks of breast hyperplasia and thrombosis associated with hormone replacement therapy, making it suitable for women who cannot use hormonal medications.
#### 3. Physical Sensation: Gentle Regulation with Low Side Effects
Common physical reactions occur in the initial period of treatment (1-2 weeks): Mild dizziness (15% incidence) and nausea (8%) may occur due to fluctuations in neurotransmitters, which generally subside after the body adapts. There is no risk of long-term liver and kidney damage, and it does not affect the menstrual cycle or metabolic indicators (such as blood sugar and lipids). It's important to note that its effects are dependent on medication-after discontinuation, neurotransmitter balance gradually returns, and the libido-enhancing effects fade within 4-6 weeks. Continued regular use is required to maintain the effects.
Flibanserin essentially works by modulating the brain's perception and response to sexual desire rather than directly stimulating the body, making it a representative "neuromodulatory" medication for female sexual desire disorders.
