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### Core Mechanism of Action: Indirect Influence of Hormonal Regulation
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The main components of HMG are follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and its connection to muscle stems from the regulation of sex hormones. It stimulates the testes to secrete testosterone, which is a recognized muscle-stimulating hormone. Testosterone promotes muscle protein synthesis by activating androgen receptors while inhibiting muscle breakdown. Furthermore, when testosterone works synergistically with growth hormone, it can further enhance muscle endurance and explosive power, creating a favorable physiological environment for muscle building. However, HMG itself does not contain the directly active ingredients required for muscle synthesis; it relies on the body's hormonal conversion chain to function.
### Research Evidence: Limited Effects and Dependence on Prerequisites
A clinical trial at the University of Washington showed that simply supplementing with growth hormone preparations (including those with HMG-related pathways) requires 12 weeks of resistance training to significantly increase lean body mass, and the increase is primarily derived from non-muscle lean tissue. Another study on hormone regulation showed that HMG-mediated testosterone increases can help maintain muscle mass in sedentary individuals or those with low hormone levels, but for well-trained athletes, the muscle-building effect is not significantly better than conventional training supplements. This means that the auxiliary effects of HMG are more likely to be observed in individuals with insufficient hormone levels.
### Safe Use and Awareness Tips
It is important to clarify that HMG is a medical preparation primarily used to treat reproductive hormone deficiency-related diseases, not a fitness supplement. Abuse may lead to side effects such as endocrine disorders, high blood pressure, and increased acne; long-term use may also damage liver function. The International Society of Sports Nutrition emphasizes that legitimate muscle gain should be achieved primarily through resistance training, adequate protein intake, and natural hormone regulation, rather than relying on hormone preparations.
For individuals aiming to build muscle, HMG is not a necessary option. It can only be used as part of medical intervention when a doctor assesses a hormone deficiency. Healthy individuals should focus on scientific training and nutrition, avoiding the indiscriminate use of hormone-based products.
