Cialis (Tadalafil) Raws Powder CAS：171596-29-5

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Cialis (Tadalafil) is a drug used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) in men. It belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil, as its active ingredient, is a commonly used drug in clinical practice with a long duration of action. It is often called the "weekend pill" because its effect can last for 48 hours, much longer than other similar drugs (such as Viagra, sildenafil).

### 1. **Physical and chemical properties**

- **Chemical name**: 2-[1-[3-(6,7-dihydro-1H-pyrrolo[3,4-b]quinazolin-1-yl)-4-ethylphenyl]-5-methyl-1H-pyrazol-4-yl]pyrimidin-4-yl]methyl (6,7-dihydro-1H-pyrrolo[3,4-b]quinazolin-1-yl) amino]methyl]pyrimidine.

- **Molecular formula**: C22H19N3O4

- **Molecular weight**: 389.41 g/mol

- **Appearance**: Tadalafil usually appears in the form of crystalline powder. As a raw powder, it is a white or off-white crystalline powder.

- **Solubility**: Tadalafil has low solubility in water, but is more soluble in alcohol solvents (such as ethanol).

### 2. **Pharmacological mechanism**

Tadalafil increases the relaxation of smooth muscles and promotes blood flow into the corpus cavernosum by inhibiting PDE5 (phosphodiesterase type 5), thereby enhancing erectile function. PDE5 usually degrades cyclic adenosine monophosphate (cGMP), which plays a key role in the male erection process. Tadalafil inhibits the activity of PDE5, thereby enhancing the effect of cGMP, promoting vasodilation, and achieving the effect of maintaining erection.

### 3. **Dosage and Usage**

Tadalafil is usually taken orally, and the common dosage is:

- **Treatment of erectile dysfunction**:

- The initial dose is usually 10 mg once daily, which can be adjusted according to effect and tolerability, with a maximum dose of 20 mg.

- Due to the long-acting nature of Tadalafil, it can also be taken as an on-demand dose, and patients can take it 30 minutes to 1 hour before planned sexual activity.

- For patients taking it daily, a lower dose (2.5 mg or 5 mg) is usually the recommended dose.

- **Benign prostatic hyperplasia (BPH)**:

- The recommended dose is 5 mg once daily, usually for continuous treatment.

- **Other uses**: Tadalafil may also be used for the treatment of pulmonary hypertension (prescription is determined by the doctor).

### 4. **Half-life and pharmacokinetics**

- **Half-life**: Tadalafil has a longer half-life of about 17.5 hours (compared to other PDE5 inhibitors, such as sildenafil, which has a half-life of 4-5 hours), so it also has a longer duration of action in the body.

- **Duration of action**: Tadalafil's effects can last up to 48 hours, so it is often called the "weekend pill."

- **Onset of action**: It usually takes effect 30 minutes to 1 hour after taking it, but in some cases it may take longer to take effect.

- **Oral absorption**: Tadalafil is absorbed by the intestines after oral administration and metabolized by the liver, mainly by the CYP3A4 enzyme system, so drug interactions may occur with certain drugs (such as certain antibiotics, antifungal drugs, etc.).

### 5. **Cycle and usage recommendations**

- **Usage cycle**: Tadalafil's effects can last for 48 hours, so it does not need to be taken frequently. For long-term treatment (such as BPH), there is usually a stable usage cycle, and it is taken for a long time under the guidance of a doctor.

- **Drug Tolerance**: Tadalafil is generally well tolerated and has relatively few side effects. It is recommended to adjust and use according to the doctor's advice.

### 6. **Side Effects**

Tadalafil's side effects are generally mild, but may also include:

- **Common Side Effects**: Headache, facial flushing, indigestion, back pain, muscle pain, nasal congestion, etc.

- **Rare but Serious Side Effects**: If you experience visual impairment, hearing loss, chest pain, difficulty breathing, or prolonged erection (erection lasting more than 4 hours), you should seek medical attention immediately.

### 7. **Drug Interactions**

Tadalafil may interact with some drugs, especially when used with drugs containing nitrates, which may cause severe hypotension (such as certain heart drugs, drugs used to treat high blood pressure, etc.). In addition, Tadalafil may also interact with certain antifungal drugs, antibiotics, or antiviral drugs.

### 8. **Use of Tadalafil Raws Powder**

As a raw powder, Tadalafil powder is usually used by pharmaceutical companies or laboratories for drug manufacturing or research. When purchasing raw powder, special attention should be paid to dosage and quality control. Tadalafil in powder form is usually not used directly for clinical or non-clinical purposes, but is used in drug manufacturing after being formulated and standardized with appropriate dosage.

### Summary

Tadalafil (Cialis) is a drug widely used to treat male erectile dysfunction and benign prostatic hyperplasia. It is widely known as the "weekend pill" because of its long duration of action. Its pharmacological action is to enhance the action of cGMP by inhibiting the PDE5 enzyme, promoting blood flow to the penis, thereby helping patients improve erectile function. Although Tadalafil has fewer side effects and is well tolerated by most patients, it is still necessary to follow the doctor's dosage and usage instructions to avoid unnecessary side effects and drug interactions.

Cialis (Tadalafil) raw material powder applicable population, working principle, usage and dosage:

### 1. Applicable population

1. **Patients with erectile dysfunction (ED)**:

- **Cialis** (Tadalafil) is mainly used to treat male erectile dysfunction (ED), also known as impotence. ED refers to the inability of men to obtain or maintain sufficient erection hardness for normal sexual activity under sexual stimulation.

2. **Patients with benign prostatic hyperplasia (BPH)**:

- Cialis is also used to treat benign prostatic hyperplasia (BPH), which is symptoms such as poor urine flow and difficulty urinating caused by enlarged prostate glands.

3. **Combined treatment**:

- Some clinical trials have shown that Tadalafil can treat men with ED and BPH at the same time, thereby improving urethral symptoms and erectile function.

4. **Patients with pulmonary arterial hypertension (PAH):

- Tadalafil can also be used to treat pulmonary arterial hypertension (PAH), improve pulmonary vascular pressure, relieve symptoms, and improve exercise capacity.

### 2. Working principle

The working principle of Tadalafil (Cialis) is mainly to increase blood flow to the penis by inhibiting **phosphodiesterase type 5 (PDE5)** and enhancing the effect of **nitric oxide (NO)**. The specific process is as follows:

1. **Nitric oxide release**: During sexual stimulation, nerve endings in the penis release nitric oxide.

2. **Inhibition of PDE5 enzyme**: Tadalafil inhibits the activity of PDE5 enzyme, which usually breaks down **cyclic adenosine monophosphate (cGMP)**. Under the action of nitric oxide, cGMP promotes smooth muscle relaxation, causes blood vessels to dilate, and increases blood flow to the corpus cavernosum of the penis, thereby achieving an erection effect.

3. **Duration of effect**: Compared with other PDE5 inhibitors (such as Viagra), Tadalafil has a longer duration of action. Its duration can be up to 36 hours, so it is called the "weekend pill". This means that after taking the medicine, erectile function can last for a long time, and it is not necessary to schedule the medication precisely according to the specific time of sexual activity.

### 3. Usage and dosage

**The usage and dosage of Cialis** (Tadalafil) usually depend on the specific treatment purpose and the individual situation of the patient.

1. **For erectile dysfunction (ED)**:

- **Regular daily dose**: Usually **2.5mg or 5mg**, once a day, patients need to take it at a fixed time every day, not restricted by the timing of sexual activity.

- **On-demand use**: If used on demand, the dose is generally **10mg or 20mg**, taken about 30 minutes to 1 hour before the scheduled sexual activity. Depending on the patient's response and tolerance, the dose can be adjusted to **5mg, 10mg or 20mg**.

2. **For benign prostatic hyperplasia (BPH)**:

- **Common dose**: The common dose is **5mg** once a day, usually used to improve urination symptoms.

3. **For pulmonary arterial hypertension (PAH)**:

- **Recommended dose**: The usual dose for treating pulmonary arterial hypertension is **40mg**, divided into two doses (20mg in the morning and 20mg in the evening).

4. **Precautions for use**:

- The dose should be adjusted according to the doctor's instructions, especially if there are other diseases (such as liver and kidney dysfunction, heart disease, etc.) or other medications are being used.

- If there is severe liver and kidney dysfunction or cardiovascular disease, high doses or on-demand doses should be avoided.

- It is necessary to pay attention to the interaction with some drugs, such as **nitroglycerin** drugs, α-receptor antagonists, etc.

### 4. Precautions and side effects

1. **Common side effects**:

- Headache, indigestion, back pain, muscle pain, facial flushing, nasal congestion, etc.

2. **Serious side effects**:

- Erection lasting more than 4 hours (abnormal penile erection, called "persistent penile erection"), you need to seek medical attention immediately.

- If you have symptoms such as blurred vision and hearing loss, you should stop using it and seek medical attention in time.

3. **Contraindications**:

- People who are allergic to Tadalafil or other PDE5 inhibitors.

- Patients who are using nitrate-containing drugs (such as nitroglycerin) at the same time, as they may suffer from severe hypotension.

### 5. Summary

Cialis (Tadalafil) increases blood flow by inhibiting the action of the PDE5 enzyme, thereby treating erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary hypertension. The dosage and method of administration vary depending on the disease and the patient's physical condition. When using, follow the doctor's advice and avoid overdose or combination with inappropriate drugs.

Cialis (Tadalafil) is a widely used drug for the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). It belongs to a class of drugs called **phosphodiesterase 5 inhibitors** (PDE5 inhibitors), commonly known as Cialis. Tadalafil is its active ingredient, which works by relaxing smooth muscles and dilating blood vessels, thereby enhancing blood flow to specific areas such as the penis, prostate, and bladder area. Cialis is usually taken in tablet form, but it can also be made into other dosage forms as a raw powder. Here are some of the main benefits of Tadalafil (Cialis) raw powder:

### 1. **Treatment of erectile dysfunction (ED)**

One of the most well-known uses of Tadalafil is the treatment of erectile dysfunction (ED). It works by inhibiting the PDE5 enzyme and enhancing the effects of nitric oxide (NO), which promotes vasodilation and enhances blood flow to the penis, thereby improving erectile ability. The effects of Tadalafil can last up to 36 hours, which makes it a clear advantage in duration compared to other PDE5 inhibitors such as Viagra.

- **Long-lasting**: Tadalafil's effects usually last for 36 hours, so it is nicknamed the "weekend pill," allowing patients to enjoy greater freedom over multiple days without having to take it every day.

- **Rapid onset**: The effects are usually felt within 30 minutes to 2 hours of taking the medication.

### 2. **Treatment of Benign Prostatic Hyperplasia (BPH)**

Benign prostatic hyperplasia (BPH) refers to an enlarged prostate gland that is common in middle-aged and older men, leading to symptoms such as frequent urination, urgency, and difficulty urinating. Tadalafil can improve urine flow and symptoms in BPH patients by relaxing the smooth muscles of the bladder and prostate, relieving urethral compression.

- **Symptom relief**: By relaxing the smooth muscles of the prostate, Tadalafil helps improve urine flow and relieve symptoms of urgency, frequency, and difficulty urinating.

- **Improved quality of life**: Improved urination function and enhanced patients' quality of life.

### 3. **Improved athletic performance**

A lesser-known benefit of Tadalafil is its potential impact on athletic performance. Some studies have shown that Tadalafil can improve endurance by increasing oxygen supply to muscles and reducing muscle fatigue.

- **Improved blood flow**: By dilating blood vessels, Tadalafil may help improve blood supply to muscles during exercise, increasing oxygen and nutrient delivery.

- **Reduced lactic acid accumulation**: Better blood flow may reduce lactic acid accumulation, thereby delaying muscle fatigue.

### 4. **Improved pulmonary hypertension**

Tadalafil is also used to treat pulmonary arterial hypertension (PAH), a disease involving increased pressure in the blood vessels of the lungs, which may lead to symptoms such as shortness of breath and fatigue. As a PDE5 inhibitor, Tadalafil can help reduce pulmonary artery pressure by dilating the blood vessels in the lungs, improving patients' symptoms.

- **Reduced pulmonary artery pressure**: By dilating the pulmonary artery blood vessels, Tadalafil helps improve blood circulation and cardiopulmonary function, relieving shortness of breath.

- **Increased exercise endurance**: Improved blood flow and oxygen supply can help patients increase their physical strength and endurance.

### 5. **Enhanced sexual function and sexual health**

Tadalafil not only treats ED, but also has some potential positive effects on sexual health. Some studies have shown that Tadalafil may improve sexual satisfaction by enhancing the response to sexual stimulation.

- **Enhanced erection hardness**: Tadalafil can enhance penile blood flow, promoting a stronger and longer-lasting erection.

- **Enhanced sexual satisfaction**: Some men report increased sexual satisfaction and overall improved sexual function after taking Tadalafil.

### 6. **Enhanced vascular health**

As a PDE5 inhibitor, Tadalafil has a certain effect on systemic vascular health in addition to its effect on penile blood flow. By relaxing smooth muscle and dilating blood vessels, Tadalafil may help reduce the risk of cardiovascular diseases such as hypertension.

- **Antihypertensive effect**: Tadalafil may help lower systemic blood pressure by relaxing blood vessels, especially for patients with mild hypertension.

- **Improved vascular elasticity**: Some studies have shown that Tadalafil may help improve vascular elasticity and reduce the risk of arteriosclerosis.

### 7. **Improved Mental Health**

Like any drug that involves sexual function, Tadalafil may also play a role in improving mental health. Erectile dysfunction is often associated with problems such as depression, anxiety, and low self-esteem, and Tadalafil may help alleviate these psychological burdens by improving sexual function.

- **Improved Self-Confidence**: By treating ED, patients may regain confidence and reduce psychological burdens.

- **Reduced Sexual Anxiety**: The sustained effect of Tadalafil allows patients to enjoy sex more relaxed and naturally, thereby reducing sexual anxiety.

### 8. **Side Effects and Safety**

Although Tadalafil has many potential benefits, it also has some possible side effects, especially at high doses. Common side effects include headache, facial flushing, stomach discomfort, back pain, and muscle pain. When used long-term, pay attention to cardiovascular health and use under the guidance of a doctor.

- **Common Side Effects**: Headache, indigestion, back pain, nasal congestion, flushing, etc.

- **Warning**: Combination with nitrate drugs may cause severe hypotension, and should be used according to the doctor's advice.

### Conclusion

Tadalafil (Cialis) is an effective drug that not only has significant effects in treating erectile dysfunction and benign prostatic hyperplasia, but may also have a positive impact on improving athletic performance, cardiovascular health, pulmonary hypertension, and overall sexual health. However, it is necessary to follow the doctor's instructions when using it to ensure the safety and effectiveness of the drug and avoid side effects. When purchasing raw powder, you need to be particularly careful to ensure that the source is reliable to avoid using inferior or non-compliant products.

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