Lidocaine Raws Powder CAS：137-58-6

### Raws Powder Lidocaine Introduction

**Lidocaine** is a local anesthetic and antiarrhythmic drug. Its raw material powder (Raws Powder Lidocaine) is an unprocessed drug form, mainly used to prepare injections, topical ointments or other dosage forms. Lidocaine is widely used in medical and scientific research fields due to its high local anesthetic effect and good safety.

### **Physical and chemical properties**

1. **Molecular formula**: C14H22N2O

2. **Molecular weight**: 234.34 g/mol

3. **Appearance**: White or off-white crystalline powder, odorless or weak odor.

4. **Solubility**:

- Soluble in water and ethanol.

- Also has good solubility in chloroform and acetone.

5. **Melting point**: 66–69°C

6. **Chemical properties**:

- It is an amide local anesthetic with a stable structure and is not easy to decompose.

- It may degrade under acidic or alkaline conditions.

### **Pharmacological action**

#### **Local anesthetic action**:

- Lidocaine blocks the sodium channels on the nerve cell membrane and inhibits the transmission of nerve impulses to achieve an anesthetic effect.

- It takes effect quickly (usually within 1–5 minutes after injection) and lasts for about 30–120 minutes, depending on the dose and administration method.

#### **Anti-arrhythmic effect**:

- In the heart, lidocaine mainly acts on Purkinje fibers and ventricular myocytes, reducing the influx of sodium ions, reducing the activity of automaticity and ectopic excitation points, and restoring normal heart rhythm.

### **Dosage**

#### **Local anesthesia**:

- **Local injection**: Each dose is 50–300 mg, adjusted according to the size of the surgical area.

- **Topical dosage forms** (such as creams or gels): Apply to painful or anesthetized areas as needed, usually no more than 200 mg/time.

#### **Anti-arrhythmic**:

- **Intravenous injection**: Initial dose is 50–100 mg, usually infused at a rate of 1–4 mg/min.

- **Maximum dose**: Generally no more than 300 mg/hour.

#### **Note**: The dose needs to be adjusted according to the patient's weight, condition, treatment purpose and administration method.

### **Half-life**

- The **plasma half-life** of lidocaine is approximately **90–120 minutes**.

- In patients with impaired liver function, its metabolism may be slowed and the half-life may be extended to **2–3 hours**.

- In the body, lidocaine is mainly metabolized by the liver to form monoethylglycine amide (MEGX) and glycine amide (GX), and finally excreted by the kidneys.

### **Action cycle**

- **Onset time**: Local anesthesia takes 1–5 minutes, and antiarrhythmic effect takes 1–2 minutes (intravenous injection).

- **Duration**: Local anesthetic effect lasts for 30–120 minutes, and antiarrhythmic effect lasts for 20 minutes to 1 hour.

### **Indications**

1. **Local anesthesia**: Applicable to surface anesthesia, infiltration anesthesia, nerve block, epidural anesthesia, etc.

2. **Antiarrhythmic**: Used to treat acute ventricular arrhythmias such as premature ventricular beats and ventricular fibrillation.

### **Precautions and side effects**

#### **Common side effects**:

1. **Local reactions**: Redness, swelling, pain or mild allergic reactions may occur at the injection site.

2. **Systemic reactions**:

- Dizziness, nausea, vomiting.

- Central nervous system symptoms such as drowsiness, anxiety or convulsions (at high doses).

- Cardiovascular symptoms, such as hypotension, bradycardia.

#### **Serious side effects**:

- **Local anesthetic toxicity** (LAST): High doses or accidental intravenous injection may lead to poisoning, manifested as convulsions, coma, respiratory depression.

- **Allergic reactions**: Including rash, itching, and in rare cases, anaphylactic shock.

#### **Contraindications**:

- People who are allergic to lidocaine or amide local anesthetics.

- Patients with severe hepatic insufficiency or renal failure (the dose needs to be adjusted carefully).

- Patients with sick sinus syndrome or heart block.

### **Usage cycle and storage**

- The usage cycle depends on the therapeutic purpose and can be short-term (acute arrhythmia treatment) or long-term (chronic pain management).

- The raw powder should be stored in a sealed dry container, away from heat and light, and the recommended storage temperature is 15–25°C.

### **Summary**

Raws Powder Lidocaine is a multi-purpose pharmaceutical raw material, widely used in local anesthesia and antiarrhythmic treatment. Its high efficiency and rapid onset of action make it an important clinical drug, but the dosage must be strictly controlled to avoid toxic or allergic reactions.

**Raws Powder Lidocaine** is a common local anesthetic widely used in the medical and beauty industries. The following is a detailed introduction to its applicable population, working principle, and usage and dosage:

### **I. Applicable population:**

1. **Patients who need local anesthesia:**

- Minor surgical procedures (such as suturing, incision and drainage).

- Dental treatment (such as tooth extraction, gum treatment).

2. **Customers in the beauty industry:**

- Local anesthesia before beauty projects such as laser hair removal, eyebrow tattooing, lip tattooing, and tattooing.

3. **Patients with neuralgia:**

- Locally used to relieve neuralgic pain (such as postherpetic neuralgia).

4. **Other people who need temporary paralysis or pain relief:**

- Local skin irritation (such as burns or mild abrasions).

### **II. Working principle:**

Lidocaine is an **amide local anesthetic** that interrupts the transmission of pain signals by blocking sodium ion channels in nerve fibers and inhibiting the depolarization of nerve cells.

Specific manifestations are:

1. **Numbing effect:** The local area loses pain sensation, but the sense of touch may be partially retained.

2. **Quick onset of action:** Generally takes effect within a few minutes after application, and the duration varies depending on the dose and purpose, usually 30 minutes to several hours.

### **III. Usage and dosage:**

#### **1. Usage:**

- **Topical:**

- Dissolve an appropriate amount of lidocaine powder in an appropriate medium (such as saline, cream base) as needed, and apply it evenly to the target area.

- If the penetration effect needs to be enhanced, plastic film can be used to wrap the covered area (wrapping method), but the time limit must be observed.

- **Injection:**

- Medical professionals can prepare it into a solution for local infiltration anesthesia or nerve block anesthesia.

#### **2. Dosage:**

- **Adults:**

- The maximum dose for external use generally does not exceed 5 grams (about 500 mg of lidocaine). The total dose within 24 hours must be controlled within the prescribed range to avoid excessive side effects.

- The maximum single dose for injection is generally 4.5mg/kg, which can be appropriately increased to 7mg/kg when adrenaline is added.

- **Children:**

- Adjust the dose according to body weight, and consult a doctor before use.

### **Fourth, precautions:**

1. **Avoid overdose:**

- Overdose may cause central nervous system toxicity, such as dizziness, convulsions, arrhythmias, and even respiratory depression.

2. **Forbidden for those who are allergic to lidocaine:**

- Patients with a history of allergy to amide local anesthetics should avoid use.

3. **Use with caution on damaged skin:**

- Skin damage or severely infected areas may accelerate drug absorption and increase the risk of poisoning.

4. **Pregnant and lactating women:**

- Use under the guidance of a doctor, and try to avoid large areas or high doses.

5. **Professional operation:**

- The injection method must be performed by professional medical personnel to ensure safety.

**Summary:**

Raws Powder Lidocaine is an effective and widely used local anesthetic, but it must be used in accordance with regulations to ensure safety and effectiveness. If there are special circumstances, please be sure to consult a doctor or professional.

Raws Powder Lidocaine is a common local anesthetic widely used in medical, dental, cosmetic and other industries. Here is a detailed introduction to its main benefits:

### **1. Powerful Local Anesthetic**

- **Fast Onset**: Lidocaine blocks nerve impulses quickly, usually within minutes.

- **Long-Lasting Action**: Anesthesia usually lasts for hours, providing effective pain relief.

- **Widely Used**: Suitable for local anesthesia before surgery, dental surgery, endoscopy and other medical procedures that require short-term anesthesia.

### **2. Pain Management**

- **Acute Pain Relief**: Lidocaine acts directly on nerve endings to quickly relieve acute pain, such as pain caused by surgical wounds, cuts or burns.

- **Chronic Pain Treatment**: It is also used to manage certain chronic pain conditions, such as neuralgia and fibromyalgia.

- **Topical Soothing**: Used to relieve discomfort caused by minor cuts, abrasions, sunburn or insect bites.

### **3. Application in the field of beauty and micro plastic surgery**

- **Auxiliary anesthesia**: During cosmetic surgery and micro plastic surgery, lidocaine is often used to relieve pain caused by injection or laser treatment, such as hyaluronic acid filling, laser hair removal, etc.

- **Comfortable experience**: Reduce discomfort during and after treatment and improve the overall experience of patients.

### **4. Safety and side effect management**

- **Local application safety**: Less absorption when applied externally, less impact on the whole body, and low risk of side effects.

- **Adjustable concentration**: The concentration of lidocaine can be adjusted as needed to meet different degrees of anesthesia needs.

### **5. Multiple dosage forms and uses**

Lidocaine powder can be made into various products through different formulations:

- **Cream**: For surface anesthesia of the skin.

- **Spray**: Suitable for throat, nasal cavity and other mucous membrane areas.

- **Injection**: Widely used in medical and dental surgery.

- **Patch**: For long-term relief of chronic pain.

### **6. Flexibility in preparing drugs**

- **Personalization**: Lidocaine powder is easily soluble in water and alcohol, making it easy to prepare customized local anesthetics.

- **Drug compounding**: It can be used in combination with other drugs, such as adrenaline, to prolong the anesthesia time and reduce local bleeding.

### **7. Auxiliary tools for medical diagnosis**

- **Diagnosis of neuropathy**: Through local anesthesia tests, it is possible to evaluate whether the pain is caused by nerve problems.

- **Auxiliary examination**: In examinations such as endoscopy or gastroscopy, lidocaine can reduce patient discomfort and improve the smoothness of the examination.

### **8. Application in sports medicine**

- **Pain relief for muscle and soft tissue injuries**: Athletes often use lidocaine to relieve local pain and restore athletic ability.

- **Injection therapy**: Injection therapy for joint or ligament injuries.

### **9. Wide range of uses in the dental field**

- **Tooth extraction and root canal treatment**: Effectively anesthetize the gums and tooth nerves to reduce pain.

- **Management of tooth sensitivity**: In some cases, lidocaine can be used to relieve tooth sensitivity.

### **10. Sex life aid**

- **Delay spray**: Many delay products contain lidocaine to help delay male ejaculation and improve the quality of sex life.

### **Precautions**

Although lidocaine has many benefits, it should be used under the guidance of a doctor or professional:

- **Avoid overdose**: Overdose may cause side effects such as abnormal heart rate, dizziness, nausea, etc.

- **Allergy monitoring**: Some people may be allergic to lidocaine, so special attention should be paid when using it for the first time.

- **Scope of application**: It is not recommended for deep trauma, severe infection or situations requiring systemic anesthesia.

The proper use of lidocaine powder can greatly improve the comfort and treatment effect in the medical, dental and beauty fields.

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