Description

Technical Parameters

Introduction

raws

product-1400-1400

Products Description

#### 1. Overview

**Methenolone Enanthate** is a synthetic steroid hormone that belongs to **dihydrotestosterone (DHT) derivatives**. Its chemical name is **1-methyl-δ1-dihydrotestosterone enanthate**. Due to its unique pharmacological properties, it is widely used in **medical fields** and **sports enhancement fields**. The compound has a longer half-life through esterification modification, making it an ideal choice for long-acting injections.

#### 2. Chemical and physicochemical properties

1. **Chemical structure**

- **Molecular formula**: C27H42O3

- **Molecular weight**: 414.62 g/mol

- **CAS number**: **303-42-4** (needs to be verified by authoritative databases such as PubChem or ChemSpider)

- **Structural features**: Add methyl (1-methyl) and δ1 double bond (reduce liver metabolic pressure) to DHT, and extend the release time through enanthate ester chain.

2. **Physical and chemical properties**

- **Appearance**: White to off-white crystalline powder.

- **Solubility**: Easily soluble in organic solvents (such as ethanol, propylene glycol), slightly soluble in water.

- **Stability**: Need to be stored away from light and at low temperature (2-8°C) to avoid oxidative degradation.

#### 3. Pharmacological mechanism

1. **Androgen receptor (AR) agonism**

- Binds to intracellular androgen receptors, promotes protein synthesis, inhibits catabolism, and enhances muscle mass and strength.

2. **Low aromatization tendency**

- Because the DHT structure cannot be converted into estrogen, side effects such as breast development (gynecomastia) and water retention are avoided.

3. **Low hepatotoxicity**

- The 1-methyl structure protects it from first-pass metabolism in the liver and is suitable for oral administration (such as Methenolone Acetate), but the enanthate form is usually used for injection.

#### 4. Indications and clinical applications

1. **Medical use**

- **Chronic wasting diseases**: such as cancer cachexia, severe burns or postoperative recovery, used to reverse negative nitrogen balance.

- **Osteoporosis**: Improve bone health by promoting bone density.

- **Anemia adjuvant therapy**: Stimulate erythropoietin (EPO) secretion.

2. **Sports Enhancement Use**

- **Muscle-building cycle**: Low water retention makes it a good choice for athletes in the pre-competition period, which can reduce subcutaneous edema.

- **Female Applicability**: Low androgenic activity (about 40% of testosterone), female users are less likely to experience masculinization symptoms.

#### 5. Core Advantages Analysis

1. **Safety Advantage**

- **No estrogenic side effects**: Avoid edema, hypertension and gynecomastia.

- **Extremely low hepatotoxicity**: Suitable for long-term treatment, especially compared with 17α-alkylated oral steroids (such as stanozolol).

2. **Pharmacokinetic Advantage**

- **Long half-life**: The half-life of enanthate is about 10-14 days, reducing the frequency of injections.

- **Stable blood drug concentration**: Reduce emotional or physical fluctuations caused by hormone fluctuations.

3. **Versatility**

- Can be used in combination with a variety of steroids (such as testosterone, trenbolone) to enhance the anabolic effect.

#### 6. Synthesis and quality control

1. **Synthesis route**

- Using dihydrotestosterone as a precursor, the target product is generated through methylation and esterification reactions, and the purity of the intermediates must be strictly controlled.

2. **Quality control standards**

- **HPLC detection**: Purity must be ≥98% (API grade).

- **Residual solvent**: Comply with ICH guidelines (such as methanol <3000ppm).

- **Microbial limits**: Meet sterile API standards (USP/EP).

#### 7. Market and regulatory status

1. **Medical market**

- **Trade name**: Primobolan® (injection), Methenolone Acetate (oral).

- **Prescription status**: Most countries list it as a controlled drug and require a doctor's prescription.

2. **Sports banned drugs list**

- Listed as a **S1 banned substance** by WADA (World Anti-Doping Agency), banned during competitions.

3. **API supply chain**

- Major producing countries: China, India, Europe (such as Germany).

- Procurement must comply with GMP certification to prevent the risk of counterfeit drugs on the black market.

#### 8. Risks and controversies

1. **Risk of abuse**

- Long-term high-dose use may lead to decreased HDL (good cholesterol), acne, and hair loss (common to DHT derivatives).

2. **Legal risks**

- Possession or distribution for non-medical purposes is a criminal offense in most countries.

#### 9. Future research directions

1. **New esterification technology**: Development of ester chains with longer half-lives (such as undecanoate).

2. **Targeted delivery system**: Nanocarriers reduce pain at the injection site.

#### Conclusion

Methenolone Enanthate occupies a special position in the medical and sports fields due to its unique metabolic stability and safety. However, its abuse potential and legal restrictions require users to use it reasonably under professional supervision. In the future, with the advancement of drug delivery technology, its clinical application value is expected to be further expanded.