Description

Technical Parameters

Introduction

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product-1400-1400

Products Description

#### 1. Overview and basic properties

**Drostanolone Enanthate** is a synthetic steroid, a derivative of dihydrotestosterone (DHT), which has its half-life extended by esterification modification (enanthate). Its chemical name is **2α-methyl-17β-hydroxy-5α-androstane-3-one enanthate**, which is a long-acting esterified form of **Drostanolone (Drostanolone)** and is widely used in medicine and competitive sports.

- **CAS number**: 472-61-3 (Drostanolone mother nucleus), the complete compound after esterification may require a specific CAS number, which needs to be confirmed by the supplier.

- **Molecular formula**: C27H42O3

- **Molecular weight**: 414.62 g/mol

- **Appearance**: White to off-white crystalline powder

- **Solubility**: Soluble in organic solvents (such as DMSO, ethanol), slightly soluble in water.

#### 2. Chemical structure and synthesis route

1. **Chemical structure**

- The core structure is based on the **5α-androstane skeleton**, with the following key modifications:

- **2α-methyl**: Enhances anti-aromatization ability and reduces estrogen conversion.

- **17β-hydroxyheptanoate**: Prolongs drug half-life and improves lipid solubility.

- The ester chain (heptanoic acid) slowly releases the active ingredient **Drostanolone** through enzymatic hydrolysis, and the effect can last for 7-10 days.

2. **Synthesis method**

- The starting material is **Drostanolone**, which is combined with heptanoic anhydride under the action of a catalyst (such as p-toluenesulfonic acid) through esterification reaction.

- The purification steps include crystallization and chromatographic separation to ensure purity>98% (HPLC).

#### 3. Pharmacological action and mechanism

1. **Androgen receptor (AR) agonist**

- High affinity binding to AR, promote muscle protein synthesis, and inhibit fat deposition.

- **Anti-estrogen properties**: no aromatization activity, no conversion to estrogen, avoid edema and male breast development.

2. **Metabolic pathway**

- Metabolized by the liver into inactive products, excreted by the kidneys.

- **Half-life**: about 7-10 days (ester chain delayed release).

3. **Medical application**

- **Breast cancer treatment**: historically used for advanced hormone-sensitive breast cancer to inhibit estrogen-dependent tumor growth (now mostly replaced by new drugs).

- **Cachexia management**: improve muscle wasting syndrome, but the application is limited.

#### 4. Application areas and usage scenarios

1. **Competitive sports and bodybuilding**

- **Fat reduction and body shaping**: by increasing fat oxidation, inhibiting cortisol, reducing subcutaneous water, shaping the appearance of "dry and hard" muscles.

- **Cycle combination**: often used in combination with Trenbolone and Winstrol, used in the 8-12 week sprint stage before the game.

- **Dose range**: 200-400 mg/week (injection), need to be combined with a low-calorie diet.

2. **Medical research**

- As a tool compound for the study of androgen receptor signaling pathways.

- Explore its potential value in metabolic diseases (such as muscular dystrophy).

#### 5. Advantages and limitations

1. **Core advantages**

- **Low estrogen risk**: No side effects such as edema and breast development, suitable for sensitive people.

- **Enhance muscle clarity**: By regulating water distribution and fat metabolism.

- **Long-term effect**: Reduce injection frequency and improve compliance.

2. **Disadvantages and risks**

- **Androgenic side effects**: Acne, hair loss (common to DHT derivatives).

- **Inhibition of endogenous hormones**: PCT (such as tamoxifen) is required to restore HPTA axis function.

- **Liver burden**: Long-term high doses may affect liver function indicators.

#### 6. Regulation and quality control

1. **Global regulatory status**

- **United States**: Schedule III controlled substances (Controlled Substances Act).

- **European Union**: Prescription drugs, non-medical use prohibited.

- **China**: Listed in the "List of Stimulants", raw material production requires a "Drug Production License".

2. **Raw material quality control**

- **Purity standard**: HPLC ≥ 98%, residual solvents (such as heptane) comply with ICH Q3C.

- **Detection method**: Mass spectrometry (MS), nuclear magnetic resonance (NMR) to verify the structure.

#### 7. Market and supply chain

1. **Major manufacturers**

- China and India are the world's major raw material suppliers, and GMP certification qualifications need to be verified.

- Price range: $800-$1200/kg (depending on purity and order volume).

2. **End users**

- Pharmaceutical companies (clinical preparations), research institutions, black market (bodybuilding field).

#### 8. Safety and ethical considerations

- **Necessity of medical supervision**: Regular monitoring of blood lipids, liver enzymes, and hematocrit.

- **Consequences of abuse**: Long-term use may lead to increased cardiovascular risks and decreased fertility.

- **Detection methods**: Mass spectrometry can trace metabolites (such as 17-keto derivatives), and the long half-life leads to a detection window of several months.

#### 9. Future research directions

1. **Development of new derivatives**: Optimize the ester chain structure to balance half-life and side effects.

2. **Targeted delivery system**: Nanocarriers reduce systemic exposure and enhance local effects.

3. **Anti-aging research**: Explore its potential in sarcopenia.

#### Conclusion

Drostanolone Enanthate, as a classic anabolic steroid, is still irreplaceable in specific fields, but its application must strictly follow medical ethics and regulations. In the future, with the advancement of precision drug design and regulatory technology, its risk-benefit ratio is expected to be further optimized.