HEPIUS Ivermectin 5mg CAS:70288-86-7

**HEPIUS brand Ivermectin** is a common antiparasitic drug widely used to treat a variety of diseases caused by parasites, such as parasitic infections, river blindness (river blindness), lymphatic filariasis, and some other helminth and ectoparasitic infections. It is a specific brand belonging to the drug class **Ivermectin**.

### 1. **Physical and chemical properties**

- **Chemical name**: Ivermectin is a natural product from **Streptomyces avermitilis**, and its structure contains multiple ring structures and different functional groups.

- **Molecular formula**: C₁₉H₃₁NO₃

- **Molecular weight**: ~ 875.56 g/mol

- **Appearance**: Usually white or off-white crystalline powder.

- **Solubility**:

- Low solubility in water, but soluble in most organic solvents, such as ethanol, acetone, chloroform, etc.

- Relatively hydrophobic, easy to bind to adipose tissue.

- **Stability**: Stable at room temperature, but sensitive to light and humidity. Avoid direct exposure to light during long-term storage.

### 2. **Pharmacology and Mechanism**

Ivermectin mainly acts on the nervous system of parasites. It binds to **γ-aminobutyric acid (GABA) receptors**, increases chloride ion permeability, inhibits nerve conduction, and thus causes paralysis and death of parasites. It also interacts with **glutamate-gated chloride channels**, which is also the key to its antiparasitic activity.

- **Harmless to humans**: Ivermectin has a low affinity for GABA receptors in humans and other mammals, so it has low host toxicity.

### 3. **Dosage**

The dose of Ivermectin is usually determined by body weight and type of infection:

- **Usual adult dose**: The standard dose for treating strong helminthiasis (such as river blindness, lymphatic filariasis, etc.) is about **150-200 micrograms/kg** of body weight, taken orally as a single dose.

- For other parasitic infections, the dose may vary.

Please note that the dose should usually be adjusted based on the doctor's advice.

### 4. **Half-life**

The **half-life** of Ivermectin is about **18-24 hours**, but its efficacy is usually longer, so it is often given as a single dose. Its concentration in the blood can gradually decrease over a few days, but its active metabolites sometimes persist for a while.

- **Plasma half-life**: about **18 hours**

- **Metabolism**: Mainly metabolized in the liver by cytochrome P450 enzymes (especially CYP3A4), and metabolites are excreted through urine and bile.

### 5. **Pharmacokinetics**

- **Absorption**: Ivermectin is slowly absorbed from the intestines, and the maximum plasma concentration (Cmax) is usually reached **1-2 hours** after taking the drug.

- **Distribution**: The drug is rapidly distributed throughout the body, especially in adipose tissue, muscle, liver and brain.

- **Metabolism and excretion**:

- Metabolized by the liver, some inactive metabolites are produced.

- Most of the drug is excreted in the feces, and a small amount is excreted in the urine.

### 6. **Use cycle**

- **Single dose**: Most infections require only one dose.

- **Continuous treatment**: Some diseases (such as river blindness) may require multiple treatments at intervals of **6-12 months**.

### 7. **Indications and efficacy**

- **Parasitic infections**:

- River blindness (Onchocerciasis)

- Lymphatic filariasis

- Strongyloidiasis

- Neurocysticercosis

- **External parasitic infections**:

- Certain parasitic infections transmitted by mosquitoes.

- Treatment of head lice and scabies.

### 8. **Side effects and contraindications**

- **Common side effects**:

- Mild headache, nausea, loss of appetite, fatigue, etc.

- Less common side effects may include rash, abnormal liver function, eye inflammation, etc.

- **Serious side effects**: If severe allergic reactions, confusion, difficulty breathing, irregular heartbeat, etc. occur, stop taking the drug immediately and seek medical help.

- **Contraindications**:

- Pregnant and breastfeeding women should use with caution, especially without medical guidance.

- Patients who are allergic to ivermectin should avoid using it.

### 9. **Precautions**

- **Drug interactions**: Ivermectin may interact with certain drugs, especially anti-epileptic drugs (such as phenytoin), certain antifungal drugs (such as ketoconazole), etc., which may increase their toxicity or reduce their efficacy.

- **Liver and kidney function**: For patients with impaired liver and kidney function, the dose may need to be adjusted.

HEPIUS brand Ivermectin is an antiparasitic drug widely used to treat a variety of diseases caused by parasites. The following is a detailed introduction to the drug's applicable population, working principle, and usage and dosage:

### Applicable population:

Ivermectin is mainly used for the following groups of people:

1. **Treatment of parasitic infections**:

- **River blindness (Onchocerciasis)**: parasitic diseases caused by filariasis.

- **Lymphatic Filariasis**: lymphatic system infections caused by filariasis.

- **Worm infections**: intestinal parasitic diseases caused by roundworms, hookworms, whipworms, and filarial worms.

- **Scabies**: skin diseases caused by scabies.

- **Pediculosis capitis**: skin infections caused by head lice.

2. **Prevention and treatment of diseases caused by other parasites**:

- **Ankylosing schistosomiasis**: Diseases caused by schistosomiasis.

- **Other infections caused by parasites**: Such as eye larvae, ear scabies, etc.

### Working principle:

Ivermectin works by interfering with the parasite's nervous system, especially by binding to the parasite's GABA (gamma-aminobutyric acid) receptors to inhibit nerve conduction. This can cause paralysis of the parasite's nervous and muscle systems, thereby killing the parasite or making it incapable of movement, and eventually being cleared by the body's immune system.

- **Mechanism of action**: Ivermectin can bind to receptors in the parasite's nervous system, especially affecting nerve conduction controlled by GABA, thereby interfering with the parasite's movement and physiological functions, causing parasite paralysis and death.

- **Broad-spectrum effect**: The drug is not only effective against parasites in the body, but also can treat skin parasites such as scabies, head lice, etc.

### Dosage and Administration:

The dosage and administration of Ivermectin will vary depending on the specific type of infection, patient weight and age. The following are common dosage and administration references:

1. **Adults and children (weighing more than 15 kg)**:

- **River blindness**: A single oral dose of 200 micrograms/kg body weight, usually taken once.

- **Lymphatic filariasis**: A single oral dose of 150-200 micrograms/kg body weight, usually taken once.

- **Scabies**: For adults and children with lower body weight, usually 200 micrograms/kg body weight is taken orally once, and can be repeated according to the doctor's advice.

- **Head lice**: Adults and children can take 200 micrograms/kg body weight orally, usually as a single dose.

2. **Children (weighing less than 15 kg)**:

- The drug dosage can be adjusted according to body weight, usually 200 micrograms/kg body weight, and the specific dosage and course of treatment should be determined by the doctor according to individual conditions.

### Precautions:

- **Contraindications**: Patients who are allergic to ivermectin or other drug ingredients should not use it.

- **Pregnant and lactating women**: Use with caution and should be used under the guidance of a doctor.

- **Patients with hepatic and renal insufficiency**: Use under the guidance of a doctor, adjust the dose or monitor relevant indicators.

- **Drug interactions**: There are potential drug interactions with certain drugs such as other antiparasitic drugs and anti-epileptic drugs. When using, you need to inform your doctor of other drugs you are taking.

### Side effects:

Although ivermectin is generally considered safe, some side effects may still occur during use, the most common of which are:

- **Skin reactions**: such as rash and itching.

- **Gastrointestinal discomfort**: such as nausea, vomiting, diarrhea, etc.

- **Nervous system reactions**: such as headache, dizziness, insomnia, drowsiness, etc.

Overall, HEPIUS brand Ivermectin is used to treat a variety of diseases caused by parasites, with significant effects, but the dose should be adjusted and monitored according to the doctor's advice when used.

**Advantages of HEPIUS Brand Ivermectin**:

Ivermectin is a broad-spectrum antiparasitic drug widely used to treat a variety of diseases caused by parasites, including nematode infections, head lice, scabies, etc. HEPIUS brand of ivermectin has its unique advantages in the market. The following are some of the brand's notable features in terms of quality, efficacy, production technology, etc.:

### 1. **High quality standards**

As a well-known pharmaceutical brand, HEPIUS is committed to producing pharmaceuticals that meet international quality standards, especially in strictly following GMP (Good Manufacturing Practice) certification requirements during the pharmaceutical production process. Each batch of HEPIUS ivermectin undergoes strict quality control, including screening of raw materials, monitoring of the production process, and testing of finished products to ensure the purity and safety of the drug.

- **Purity and Content**: HEPIUS brand ivermectin usually has higher purity and low impurity content to ensure maximum efficacy.

- **Consistency**: Through strict quality management systems, HEPIUS brand ivermectin products have high batch consistency.

### 2. **Excellent efficacy**

Ivermectin is an effective antiparasitic drug. Through precise dosage design, HEPIUS brand ivermectin can eliminate parasites in the body in a short time and relieve clinical symptoms caused by parasites. It has shown significant efficacy in treating a variety of parasitic infections, particularly in the following areas:

- **Nematode infection**: such as ankylostomiasis, Taenia solium, schistosomiasis, etc.

- **External Parasites**: Skin parasites such as head lice, scabies, demodex, etc.

- **helminthic eye diseases**: such as eye infections caused by roundworms in the eye.

HEPIUS ivermectin still maintains good efficacy against many drug-resistant parasite strains, so it is one of the first-choice drugs for the treatment of many parasitic diseases.

### 3. **Broad spectrum antiparasitic effect**

HEPIUS Ivermectin's anti-parasitic effect covers a wide range of areas, not only limited to common parasite types, but also effective against parasites that are resistant to other anti-parasitic drugs. It inhibits the nervous system function of the parasite, causing the parasite to die.

- **Wide adaptability to various parasites**: HEPIUS Ivermectin is not only widely used in the treatment of common parasitic infections, but is also effective against some rare or highly drug-resistant parasites.

### 4. **High security**

HEPIUS brand ivermectin has been shown to have fewer side effects in clinical trials and long-term use. In most cases, the drug may cause adverse reactions only when taken in high doses or in overdose. Common adverse reactions include mild headache, dizziness, nausea, diarrhea, etc.

- **Suitable for adults and children**: HEPIUS brand ivermectin is suitable for adults and children of different ages (the dosage is adjusted according to weight), and is highly safe within the appropriate dosage range.

- **Low Toxicity**: Compared with many other antiparasitic drugs, ivermectin has lower toxicity during treatment, with fewer and controllable adverse reactions during use.

### 5. **Better bioavailability**

HEPIUS Ivermectin adopts an optimized formula and production process, making it highly bioavailable in the body. This ensures that the active ingredients of the drug are better absorbed and work, thereby improving efficacy.

- **Fast drug absorption**: The pharmaceutical ingredients of HEPIUS Ivermectin can enter the blood circulation quickly and produce significant therapeutic effects.

- **Long half-life**: The half-life of the drug in the body is relatively long, which can effectively maintain the sustained effect of the drug and reduce the frequency of administration.

### 6. **Widely used**

In addition to treating parasitic infections in humans, HEPIUS brand ivermectin is also widely used in the veterinary field to treat various parasitic diseases in animals, such as internal and external parasites in sheep, cattle, dogs and other pets.

- **Common use between humans and animals**: HEPIUS ivermectin is suitable for the treatment of human diseases and can also be widely used in veterinary treatment, with strong cross-field adaptability.

### 7. **Reasonable price and high cost performance**

HEPIUS brand ivermectin has received high cost-effectiveness evaluation in the market due to its relatively reasonable price and efficient therapeutic effect. Compared with other brands, HEPIUS ivermectin does not compromise on quality, and its price is relatively affordable, making it affordable to a wide range of patient groups, especially in developing countries, with wider application prospects.

### 8. **Advanced production technology**

HEPIUS adopts modern pharmaceutical processes, such as high-precision synthesis technology and efficient formulation technology, to ensure product consistency and stability. The advanced technology used in its production process not only ensures product quality, but also reduces production costs, thereby providing consumers with more competitive prices.

### 9. **Brand reputation and technical support**

HEPIUS brand has rich pharmaceutical experience and technology accumulation. Its R&D team has deep technical reserves in the field of anti-parasitic drugs and maintains close cooperation with multiple scientific research institutions and pharmaceutical companies around the world to ensure that its drug R&D and innovation capabilities remain at the leading level in the industry.

In addition, the HEPIUS brand also provides complete after-sales service and technical support to help doctors and patients obtain the best therapeutic effects when using ivermectin.

### Summarize:

HEPIUS brand ivermectin relies on its highest quality production standards, broad-spectrum antiparasitic efficacy, high safety and bioavailability, long duration of efficacy, reasonable price and advanced production The technology is excellent and has obvious competitive advantages in the global market. It is not only one of the first-choice drugs for clinical treatment of parasitic infections, but also highly praised by medical staff and patients because of its good cost performance.

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