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Product Introduction
Name:Dostinex(Cabergoline)
Product Benefits:Treatment of Parkinson's disease, hyperprolactinemia
CAS:81409-90-7
Capacity:0.25mg*100/bottle
Product Form:Tablets
Shelf Life:2-3Years(The product packaging date shall prevail)
What is HEPIUS Dostinex(Cabergoline)
HEPIUS Dostinex (Cabergoline) is an important pharmaceutical product. Here is a detailed introduction:
1. Basic information
Generic name: Cabergoline
English name: Dostinex (Cabergoline Tablets)
Trade name: HEPIUS Dostinex (may vary depending on the manufacturer or region)
2. Drug type and ingredients
Type: Cabergoline is a synthetic ergot derivative and a dopamine receptor agonist.
Main ingredients: Each Dostinex tablet contains 0.5 mg of cabergoline and other excipients such as lactose.
3. Indications
Parkinson's disease: Cabergoline can be used to treat Parkinson's disease by stimulating dopamine D2 receptors to improve patients' movement disorders.
Hyperprolactinemia: Cabergoline can inhibit the secretion of prolactin by the anterior pituitary gland and reduce the level of prolactin in the blood, thereby treating hyperprolactinemia caused by idiopathic or pituitary adenoma and its related symptoms, such as irregular menstruation and infertility.
Pituitary prolactinoma: Cabergoline is also used to treat pituitary prolactinoma, helping to reduce tumor size and control symptoms.
4. Medication Guide
Usage: Oral. Cabergoline is usually administered with food to improve its tolerability.
Dosage:
For hyperprolactinemia, the recommended initial dose is 0.5 mg per week, which can be taken once or twice (for example, 0.25 mg each on Monday and Thursday). Subsequently, the dose is gradually increased every month, usually by 0.5 mg per week, until the best effect is achieved.
When used to inhibit milk secretion, the recommended therapeutic dose regimen is 0.25 mg (half of a 0.5 mg tablet) every 12 hours for two days (total dose of 1 mg).
The maximum dose should not exceed 3 mg per day and should be adjusted according to the patient's tolerance and treatment response.
5. Side effects and precautions
Side effects: Adverse reactions such as nausea, vomiting, dizziness, orthostatic hypotension and even syncope may occur in the early stage of medication. Long-term use may cause skin reticular livedo, peritoneal fibrosis, pleural thickening and effusion. When using higher doses, symptoms such as psychosis, hallucinations, delusions, and mental confusion may also occur.
Precautions:
It is contraindicated for those who are allergic to cabergoline or any excipients.
It is contraindicated for those with severe ischemic heart disease, peripheral vascular disease, children under 15 years old, pregnant women and lactating women.
It should be used with caution in those with a history of severe mental illness.
Like other ergot derivatives, it should be used with caution in patients with severe cardiovascular disease, Raynaud's syndrome, renal insufficiency, peptic ulcer or gastrointestinal bleeding.
Avoid drinking alcohol during the use of cabergoline to avoid increasing gastrointestinal adverse reactions.
6. Storage method
Cabergoline should be stored at controlled room temperature (2025℃, 6877℉) and kept dry.
In summary, HEPIUS Dostinex (Cabergoline) is an important dopamine receptor agonist, mainly used to treat diseases such as Parkinson's disease, hyperprolactinemia and pituitary prolactinoma. When using it, you should strictly follow the doctor's instructions and pay attention to the side effects and precautions of the drug to ensure safe and effective treatment.
How does HEPIUS Dostinex (Cabergoline) work?
The working principle of HEPIUS Dostinex (cabergoline) is mainly based on its characteristics as a long-acting dopamine D2-receptor agonist:
1. Main mechanism of action
Cabergoline promotes the release of dopamine, thereby feedback inhibiting the function of the hypothalamus. This mechanism of action enables the anterior pituitary to reduce the secretion of prolactin, thereby achieving the purpose of treating various diseases caused by excessive prolactin secretion.
2. Specific process of action
Promote dopamine release: Cabergoline can bind to dopamine D2-receptors, thereby activating the dopamine system and promoting the release of dopamine.
Feedback inhibition: After dopamine is released, it will act on the prolactin inhibitory factor (PIF) in the hypothalamus, enhancing its inhibitory effect on the anterior pituitary.
Reducing prolactin secretion: Under the inhibitory effect of PIF, the anterior pituitary reduces the secretion of prolactin, thereby improving the related symptoms caused by excessive prolactin.
3. Indications
Cabergoline is mainly used to treat the following diseases:
Hyperprolactinemia: diseases caused by excessive secretion of prolactin, such as menstrual disorders, infertility, galactorrhea, amenorrhea, etc.
Pituitary prolactinoma: a prolactin cell adenoma secreted by the anterior pituitary gland. Cabergoline can shrink the tumor and improve related symptoms.
Male fertility problems: such as decreased sperm count and decreased sperm motility, cabergoline can improve these symptoms by regulating prolactin levels.
4. Precautions
Regular examination: During the use of cabergoline, patients need to undergo regular related examinations, such as prolactin level determination, pituitary tumor imaging examination, etc., so that doctors can understand the changes in the condition in time and adjust the treatment plan.
Adverse reactions: Cabergoline may cause some adverse reactions, such as nausea, vomiting, headache, hypotension, etc. During use, if the patient feels unwell, he should seek medical attention and inform the doctor in time.
Special populations: Pregnant women, lactating women, children, and patients with hepatic and renal insufficiency should be particularly cautious when using cabergoline and should use it under the guidance of a doctor.
How to use HEPIUS Dostinex (Cabergoline) correctly
HEPIUS Dostinex (Cabergoline) is generically known as cabergoline, a synthetic ergot derivative and a dopamine agonist similar to bromocriptine. The following is a detailed introduction to its applicable population and correct usage methods:
1. Applicable population
Cabergoline is mainly used to treat patients with the following diseases:
Hyperprolactinemia: including idiopathic or pituitary adenoma-induced hyperprolactinemia.
Parkinson's disease: used to improve symptoms in patients with Parkinson's disease.
Breast cancer: In some cases, cabergoline is also used to treat breast cancer.
Fertility problems: can be used to treat male and female fertility problems, such as fertility disorders caused by excessive prolactin.
Acromegaly: In the treatment of acromegaly, cabergoline can help control the secretion of growth hormone.
In addition, cabergoline can also be used to induce estrus, synchronize estrus, and as an abortion drug for animals (but it is contraindicated for pregnant cats and dogs unless the purpose is to induce abortion).
2. Correct use method
Dose adjustment:
Adult hyperprolactinemia dosage: The initial dose is usually 0.25 mg, orally twice a week. According to the patient's prolactin level, increase the dose in increments of 0.25 mg, twice a week, for no more than 4 weeks each time. The maximum dose is 1 mg twice a week. Patients should maintain the lowest dose that provides the maximum response.
Animal medication: The dosage varies according to the animal species and weight, and a veterinarian should be consulted for specific details.
Time of medication:
Cabergoline is usually taken after meals or with food to reduce gastrointestinal adverse reactions.
When used to suppress mammary secretion after delivery, it should be taken at least 4 hours after delivery, and the heart rate, blood pressure and respiration should be stable before the medication can be used.
Monitoring and follow-up:
During treatment, patients should undergo regular related examinations, such as serum prolactin levels, sella turcica X-rays, CT or MRI examinations, etc., to understand the changes in pituitary tumors.
When used to treat patients with amenorrhea, pregnancy tests should be performed regularly.
When treating infertility, female patients need to measure basal body temperature every day and serum hormone levels every month to monitor ovulation or pregnancy.
3. Precautions:
People who are allergic to ergot preparations are prohibited from using this drug.
People with severe ischemic heart disease and peripheral vascular disease are prohibited from using this drug.
Children under 15 years old are prohibited from using this drug.
Pregnant women and breastfeeding women are prohibited from using this drug (but pregnant women who are treating pituitary prolactinomas can continue to use this drug to prevent the tumor from growing during pregnancy).
People with hypertension or a history of hypertension, pregnancy-induced hypertension syndrome, or a history of pregnancy-induced hypertension should use this drug with caution.
People with acromegaly who have a history of ulcer disease or bleeding should use this drug with caution.
Avoid using this drug with dopamine antagonists (such as metoclopramide or phenothiazines) because these drugs can reduce the effect of cabergoline.
When used with other antihypertensive drugs, it may lead to an additive effect of lowering blood pressure, so it should be used with caution.
Alcohol should not be consumed during medication because combined use with ethanol can increase the body's sensitivity to ethanol and increase gastrointestinal adverse reactions.
Discontinuation and restart of treatment:
After maintaining normal serum prolactin levels for 6 months, the drug can be discontinued and serum prolactin levels can be tracked to determine whether treatment needs to be restarted.
If adverse reactions or suspected pregnancy occur, the drug should be discontinued immediately and medical attention should be sought.
In short, cabergoline is an effective therapeutic drug, but when using it, it is necessary to strictly follow the doctor's instructions and the medication instructions in the instructions to ensure safe and effective efficacy.
What are the benefits of HEPIUS Dostinex (Cabergoline)
HEPIUS Dostinex (Cabergoline) is a synthetic ergot derivative and a long-acting dopamine receptor agonist. It is mainly used to treat a variety of diseases. The following are its main benefits:
1. Treatment of hyperprolactinemia
Main application: Cabergoline can effectively treat hyperprolactinemia caused by idiopathic or pituitary adenoma. It acts on dopamine receptors to reduce excessive secretion of prolactin, thereby improving related symptoms such as irregular menstruation and infertility.
Mechanism of action: Cabergoline can inhibit the synthesis and secretion of PRL (prolactin) at the hypothalamic and pituitary levels and reduce the level of PRL in serum.
2. Treatment of Parkinson's disease
Relieve symptoms: Cabergoline can be used alone or in combination with levodopa to reduce symptom fluctuations in patients with Parkinson's disease, such as muscle stiffness and bradykinesia.
Improve quality of life: By reducing the occurrence of symptoms, cabergoline helps improve the quality of daily life of patients with Parkinson's disease.
3. Other potential benefits
Breast cancer treatment potential: Although the evidence is not yet sufficient, cabergoline's agonistic effect on dopamine receptors may be effective for some breast cancer patients.
Application in veterinary field: In the veterinary field, cabergoline is also used to regulate the reproductive cycle of dogs, such as inducing estrus, treating pseudopregnancy, and terminating pregnancy. In addition, it can be used with or without prostaglandins for terminating pregnancy in cats.
4. Precautions for medication
Side effects: Cabergoline may cause a series of side effects, such as nausea, vomiting, dizziness, and orthostatic hypotension. At higher doses, psychosis, hallucinations, delusions and other mental symptoms may also occur. Therefore, patients should pay close attention to their own reactions when using it and adjust the dose under the guidance of a doctor.
Contraindications: Cabergoline is contraindicated for pregnant cats and dogs (unless intended for abortion), as well as patients who are allergic to ergot derivatives or have uncontrolled hypertension.
5. Storage and preservation
Storage conditions: Cabergoline should be stored in a dark, dry place indoors, with the temperature controlled between 20 and 25°C.
Note: Do not share the drug with people who have the same symptoms, and keep the drug away from children.
In summary, HEPIUS Dostinex (Cabergoline) has significant benefits in the treatment of hyperprolactinemia and Parkinson's disease, and also shows certain application potential in breast cancer treatment and veterinary medicine. However, patients should pay close attention to side effects and contraindications when using it, and use it reasonably under the guidance of a doctor.
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FAQ
Q: What is Cabergoline?
A: Cabergoline is a synthetic ergot derivative that is a dopamine receptor agonist. It is used primarily to treat Parkinson's disease, hyperprolactinemia, and pituitary prolactinomas. By stimulating dopamine D2 receptors, cabergoline inhibits the secretion of prolactin from the anterior pituitary, thereby reducing prolactin levels in the blood.
Q: In what cases is Cabergoline used?
A: Cabergoline is used primarily in humans to treat disorders associated with hyperprolactinemia and Parkinson's disease. In animals, it can be used in dogs to induce estrus, treat primary and secondary anestrus, pseudopregnancy, and terminate pregnancy in the late stages of pregnancy. For cats, cabergoline can be used with or without prostaglandins for pregnancy termination, especially in the early stages of pregnancy.
Q: How is Cabergoline dosed?
A: For adult patients with hyperprolactinemia, the initial dose is usually 0.25 mg orally twice a week. Depending on the patient's prolactin level, the dose can be gradually increased in 0.25 mg increments twice a week, but each increment should not exceed 4 weeks. The maximum dose is 1 mg twice a week. Patients should remain on the lowest dose that provides the greatest response, and after maintaining normal serum prolactin levels for 6 months, consider discontinuing the drug and follow up serum prolactin levels to determine if treatment needs to be restarted.
Q: Can Cabergoline be used with other medications?
A: When using Cabergoline, special attention should be paid to interactions with other drugs. For example, it may increase the risk of heart valve disease when used in combination with some heart medications (such as quetiapine). In addition, when used simultaneously with blood pressure medications and antipsychotics (such as phenytoin and chlorpromazine), their adverse reactions may be increased. Therefore, before using Cabergoline, be sure to tell your doctor about other medications you are using to avoid possible interactions.
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